| Cell
Signaling Pathways
Reinterpretation
of structural and sequence data of the death domain superfamily
of proteins involved in programmed cell death signaling. Apoptosis
is a signaling pathway crucial to normal cell development and
dysfunction causes a myriad disease states from cancers to autoimmune
diseases. We reinterpreted existing structural data to glean
novel protein-protein interaction information and proposed a
novel model for the DISC complex that will prompt novel experiments
not only in DISC research but the entire death domain superfamily.
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Weber,
C.H. & C. Vincenz (2001) The death domain superfamily. TIBS
26:475-481.
Weber,
C.H. & C. Vincenz (2001) A docking model of key components of
the DISC complex: death domain superfamily interactions redefined.FEBS
Lett. 492:171-176.
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